Leukocyte Common Antigen (LCA) Cocktail 1,0 mL

Specificity and Comments:

CD45 recognizes an antigen found on lymphoid cells. Most neoplastic B cells and T cells stain positively in leukemia and in non-Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are generally negative. It is unreactive with epithelium and connective tissues. The PD7/26 and 2B11antibody was included in the 4th International Workshop and was designated as CD45. It belongs to a LCA family of glycoproteins with molecular weights of 180, 190, 205 and 220. It is well suited for formalin-fixed paraffin-embedded tissues and is used as a pan lymphocyte screener for lymphoma.

 

 

Species Reactivity: Human; others not tested.

 

Clone: PD7/26/16 and 2B11

 

Isotype: IgG1/Kappa

 

Immunogen:

PD7.26.16: Human peripheral blood lymphocyte 2B11: Neoplastic cells from T-cell lymphoma

 

Known Applications: Immunohistochemistry

(formalin-fixed paraffin-embedded tissues)

Positive Control: Tonsil or lymphoma

 

Cellular Localization: Cell membrane

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store at 4°C. Antibody is stable for 18 months.