Epidermal Growth Factor Receptor (EGFR) 0,1 mL

Specificity and Comments:

EGFR recognizes a 170kDa protein, identified as the first member (EGR-Receptor) of type I family of growth factor receptors. It shows no cross-reaction with c-erbB-2, cerbB-3 or c-erbB-4. Over-expression of EGFR is reported in tumors of breast (25%), brain, bladder, lung, gastric, esophagus, cervix, ovary and endometrium.

 

 

Species Reactivity: Human

 

Clone: 111.6

 

Isotype: IgG1

 

Immunogen:

Extracellular domain of human recombinant EGFR

 

Known Applications: Immunohistochemistry (formalin–fixed paraffin embedded tissues)

 

Positive Control:

Squamous cell carcinoma or colon cancer

Cellular Localization:

Cell membrane and some cytoplasmic

 

Supplied As:

1. Buffer with protein carrier and preservative

2. 1.5 ml conc. Pronase (Cat # PRT957Q)

3. 6.0 ml of Pronase Buffer (Cat # PRB957G)

 

Storage and Stability:

Store vial at 4°C. Product is 18 months.