Calretinin
is a calcium binding protein that is related to calmodulin and calbindin-D28k
and is found mainly in neuronal tissue. It is present in subsets of neurons
throughout the brain and spinal chord, including sensory ganglia. Studies have
shown that calretinin, like calbindin, may be neuroprotective.
Immunohistochemical studies have also recently shown calretinin to be
useful in distinguishing mesotheliomas from lung adenocarcinomas. However, it is
recommended that a panel of antibodies be used in tandem with calretinin. Other
antibodies recommended are CK 5/6, E-cadherin, WT -1, CEA, B72.3, Vimentin and
D2-40. Calretinin does not mark all mesotheliomas
(80-90%).