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BOB-1 0.1 mL
Tonsil stained with BOB-1 antibody
BOB-1 0.1 mL
BC-CM418A
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Description
Specifications
Intended Use
IVD
Source
Mouse Monoclonal
Species Reactivity
Human
,
Others not tested
Clone
TG14
Isotype
IgG2b
Antigen
Prokaryotic recombinant protein containing 116 amino acids of the C-terminus of BOB-1
Cellular Localization
Nuclear
Positive Control
Tonsil
Normal Tissue
Tonsil
Abnormal Tissue
B-cell lymphoma
BOB-1 (B-cell specific octamer binding protein-1) protein is a B-lymphocyte-specific transcriptional coactivator. It interacts with Oct-1 and Oct-2 transcription factors. BOB-1 and Oct-2 play essential roles in germinal center formation and immunoglobulin production. BOB-1 has been reported to be detectable in all B-cell populations found in reactive lymphoid tissues, the strongest expression being found in germinal center Bcells and plasma cells. BOB-1 and Oct-2 are most useful for the B-lineage determination of CD20-plasmablastic, or primary effusion subtypes of diffuse large Bcell lymphoma (DLBCL). Other studies have shown BOB.1, CD79a and Cyclin E are the most appropriate markers to discriminate classical Hodgkin’s lymphoma from primary mediastinal large B-cell lymphoma. The strong nuclear expression of BOB-1 and Oct-2 by germinal center derived lymphomas makes these antibodies a novel class of broad spectrum B-lineage immunohistochemical markers in the differential diagnosis of lymphomas.
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