The Bcl-6 gene, originally cloned from
a tumor with 3q27 translocation, is commonly expressed in large cell lymphomas.
In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed
to be important in germinal center formation. Bcl-6 is expressed mainly by
follicle center cells and in a few interfollicular Tlymphocytes. Bcl-6 has also
been detected in Burkitt’s lymphoma and in nodular lymphocyte predominant
Hodgkin’s disease. Bcl-6 is not expressed in hairy cell leukemia, mantle cell or
marginal-zone derived lymphomas. This antibody demonstrates strong nuclear
reactivity.