| SPECIES REACTIVITY |
Human
|
| SOURCE |
Mouse Monoclonal
|
| CLONE |
34ßE12
|
| ISOTYPE |
IgG1/kappa
|
| ANTIGEN |
HMW CK [34ßE12]
|
| LOCALIZATION |
Cytoplasmic
|
| POSITIVE CONTROL |
Skin, prostate or squamous cell carcinoma
|
Cytokeratin HMW [34ßE12] antibody recognizes Cytokeratins 1, 5, 10 and 14. This antibody is expressed in squamous and adenosquamous carcinomas and is negative in adenocarcinomas. In normal epithelia, [34ßE12] stains stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi. It is also expressed in ductal and squamous epithelium over a wide range of organ tissues. Studies have shown that [34ßE12] is useful as a differential marker for squamous carcinomas and adenocarcinomas as well as for benign and malignant tumors of the prostate gland.