CD3 (T-Cell) 1,0mL
Specificity and Comments:
Monoclonal antibody to human CD3, when used in conjunction with other antibodies, is regarded as a reliable pan T-cell antibody used in the immunophenotyping of lymphomas in paraffin sections. This CD3 monoclonal does not react with B-cells. However, UCHL-1 and polyclonal CD3 antibodies have been shown to mark small subsets of B cells. Most T-cell lymphomas show positivity for CD3. Notable exceptions include some of the more aggressive, high-grade T cell lymphomas, which may not express detectable antigen. Used in conjunction, UCHL-1 and monoclonal CD3 together identified the vast majority of T-cell lymphomas in paraffin sections. (See reference)
Species Reactivity: Human; others not tested.
Clone: PS1
Isotype: IgG2a
Immunogen:
Prokaryotic fusion protein corresponding to the epsilon chain of CD3
Known Applications: Immunohistochemistry
(formalin-fixed paraffin-embedded tissues)
Positive Control: Tonsil or T-cell lymphoma
Cellular Localization:
Predominantly cell membrane, some cytoplasmic
Supplied As:
Buffer with protein carrier and preservative
*Includes Renoir Red Diluent (PD904JJ)
and BORGDECLOAKER (BD1000MM)
**Includes Renoir Red Diluent (PD904H)
and BORGDECLOAKER (BD1000S-250)
Storage and Stability:
Store vial at 4°C. Stable for 18 months.