CD79a/mb-1 (B-cell) 1,0mL

Specificity and Comments:

CD79a is an intracellular component of the signal transduction pathway of the B-Cell Receptor (BCR). CD79a first appears at pre-B-cell stage, early in maturation. It persists until the plasma cell stage, when it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor-B-cell type. It is also found in B-cell lines, B-cell lymphomas, and in some myelomas. It is not present in myeloid or T-cell lines. In a study by Mason, et al (Blood, 1995) on a total of 454 paraffin-embedded tissues, it reacted with 97% of B-cell neoplasms. This antibody labels precursor B-cell acute lymphoblastic leukemia samples, making it the most reliable B-cell marker for this disorder. It is therefore highly recommended that CD79a be used in conjunction with CD20 [L26] for the identification of B-cell neoplasms. Key Reference: Mason (1995). CD79a for B Cell is conserved across many species. Therefore, this antibody may be useful in the identification of lymphocyte subsets in species other than human.

 

 

Species Reactivity:

Human, Monkey, Horse, Cow, Pig, Dog, Rabbit, Guinea pig, Rat, Mouse, Chicken (Plasma cells)

 

Clone: HM47/A9

 

Isotype: IgG1 / ?

 

Immunogen:

Synthetic peptide consisting of

GTYQDVGSLNIADVQ of human CD79a protein

 

Known Applications: Immunohistochemistry (formalin–fixed, paraffin-embedded tissues).

 

Positive Control:

Germinal center B cells in a lymph node or tonsil.

 

Cellular Localization: Cell membrane

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage and Stability:

Store vial at 4°C. Stable for 18 months.