ChromograninA Cocktail 1,0 mL
Specificity and Comments:
Recognizes a protein of 68-75kDa, identified as chromogranin A (a protein of 439-amino acid which is encoded on chromosome 14). Although the epitopes for [LK2H10] and [PHE5] are not precisely mapped, experimental data suggest that they are different (a cocktail of LK2H10 and PHE5) is especially designed for sensitive detection of Chromogranin A in formalin-fixed, paraffin-embedded tissues. Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
Species Reactivity: Human and Monkey
Clone: LK2H10 + PHE5
Isotype: IgG1 + IgG1
Immunogen: Human pheochromocytoma
Hybridoma:
Produced by fusion between BALB/c splenocytes and myeloma p3-NS1-Ag4-1 cells.
Known Applications: Immunohistochemistry (formalin-fixed paraffin-embedded)
Positive Control:
Pancreas, adrenal gland, bowel, thyroid
Cellular Localization:
Finely granular cytoplasmic
Supplied As:
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.