In normal epithelia, HMW Cytokeratins
(CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in
prostate basal epithelial nuclei in normal prostate, however, is negative in
malignant tumors of the prostate gland. Thus p63 is useful as a differential
marker for benign and malignant tumors of the prostate gland and can be useful
as a negative marker. Prostate – 2X can be used in combination with an
additional antibody to generate a PIN-4 combination (see technical
notes).
| INTENDED USE
|
IVD |
| SPECIES REACTIVITY
|
Human |
| SOURCE |
Mouse Monoclonal
|
| CLONE |
XM26/LL002 + 4A4
|
| ISOTYPE |
IgG1/kappa IgG3
IgG2a/kappa
|
| ANTIGEN |
CK5 CK14 p63
|
| LOCALIZATION |
Cytoplasmic and
nuclear
|
| POSITIVE CONTROL
|
Normal
prostate
|